Asia PR News

MELBOURNE, April 27/MediaNet International-AsiaNet/ –

A report by the Australian Heart Foundation states that cardiovascular
disease will rise from one-in-six to one-in-four by 2051, according to a report
released in 2005. This is reflected in the number of patients undergoing
coronary artery bypass (CABG) surgery, which has grown rapidly in the past
couple of decades, particularly in Australia and the US. CABG surgery is
performed about 400,000 times annually in the US alone, making it one of the
most commonly performed major operations.

CABG surgery is advised for selected groups of patients with significant
narrowings and blockages of the heart arteries (coronary artery disease). CABG
surgery creates new routes around narrowed and blocked arteries, allowing
sufficient blood flow to deliver oxygen and nutrients to the heart muscles.

Impaired cognition is a known complication of these procedures and some
loss of brain function has been reported in up to 70% of patients at
discharge. There is currently no treatment.

Neuren Pharmaceuticals successfully completed its Phase 2 trial of its
brain protectant drug, Glypromate, at five sites in Australia and New Zealand
including the Alfred Hospital in Melbourne, last week. The trial involved 33
patients undergoing CABG surgery and was aimed at assessing the safety of
Glypromate.

Neuren will now speak to the US regulatory body, Food and Drug
Administration (FDA), in preparation for a Phase 3 trial to test the efficacy
as a protectant from neurocognitive disturbance following CABG surgery of
Glypromate planned for later this year. The Phase 3 trial will involve 520
patients at sites in Australasia, the United States and in Europe. Neuren will
be one of very few Australian-listed biotechnology companies entering Phase 3
this year.

Due to the lack of treatment in this area, and the increasing need, the FDA
has intimated it fast track the process of Glypromate route to market. This is
very unusual for the FDA to do and highlights the significance of these trials.

What is CABG?
A Coronary artery bypass graft (CABG) is an operation to bypass a narrowed
or blocked segment of a coronary artery using a graft.
Usually, this graft is a length of vein taken from the leg (saphenous vein)
although, often a small length of artery from the chest wall (internal mammary
artery) and/or occasionally the arm is used - it is quite usual to need two,
three or even four grafts.

The grafts taken from the leg and forearm are connected to the aorta at one
end while the other end is attached to the coronary artery, bypassing the
blockage or narrowing. If the internal mammary artery is used as a graft, it
usually remains attached to its own blood supply, with its end sewn onto the
coronary artery.

All grafts are sewn to the affected artery bypassing the narrowed part,
thus providing a new channel which blood can flow through to the heart muscle.
As a result, there will be an improvement in blood flow and relief to angina
symptoms.

Benefits of surgery
CABG surgery is performed primarily to relieve angina symptoms. By
improving the blood flow to the heart muscle, surgery can result in a more
active and better quality of life, with less or no angina and less medication.
Lifestyle changes can also help prevent a recurrence

Taken from National Heart Foundation of New Zealand website

About Neuren Pharmaceuticals
Neuren Pharmaceuticals (ASX: NEU) is a biotechnology company developing
novel therapeutics in the fields of neurotherapy and metabolic disorders. The
Neuren portfolio consists of six product families, targeting markets with large
unmet needs and limited competition. Neuren has two lead candidates,
Glypromate® and NNZ-2566, targeting a range of acute and chronic neurological
conditions. Neuren has commercial and development partnerships, including
Pfizer, the US Army’s Walter Reed Army Institute of Research and Metabolic
Pharmaceuticals.

For more information, please visit Neuren’s website at www.neurenpharma.com

Contact details

Company
David Clarke
CEO of Neuren
T: 1800 259 181 (Australia)
T: +64 9 3 367 7167 ext 82308 (New Zealand)
M: +64 21 988 052

Media and investor relations
Rebecca Piercy
Buchan Consulting
T: +61 2 9237 2800
M: +61 422 916 422

Source: Neuren Pharmaceuticals